Hartmuth C. Kolb,Joseph C. Walsh,Wei Zhang,Peter J. H. Scott,Kai Chen,Vani P. Mocharla,Dhanalakshmi Kasi,Gang Chen,Eric Wang,Anjana Sinha
申请号：
US12372717
公开号：
US08318132B2
申请日:
2009.02.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed here in are compounds and methods of diagnosing Alzheimers Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimers Disease.
