Anna Katrin Szardenings,Hartmuth C Kolb,Joseph C Walsh,Gang Chen,Umesh B Gangadharmath,Dhanalakshmi Kasi,Changhui Liu,Anjana Sinha,Eric Wang,Chul Yu,Wei Zhang,Kai Chen,Vani P Mocharla,Peter J. H. Scot
申请号：
US14513486
公开号：
US20150030540A1
申请日:
2014.10.14
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed here in are compounds and methods of diagnosing Alzheimers Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled carbazoles and derivatives thereof and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimers Disease.
