Hartmuth C. Kolb,Joseph C. Walsh,Wei Zhang,Umesh B. Gangadharmath,Dhanalakshmi Kasi,Kai Chen,Anjana Sinha,Eric Wang,Gang Chen,Peter J. H. Scott,Henry Clifton Padgett,Qianwa Liang,Zhiyong Gao,Tieming Z
申请号：
US12509259
公开号：
US08420052B2
申请日:
2009.07.24
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Downs syndrome, familial Alzheimers Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.
