A composition having anti-proliferative activity against cancer cell lines containing natural 6,7-dihydroxy-2,4-dimethoxy phenanthrene compound from D. batatas Decne
invention saengma of Joie (Young Woman) derived from 6,7-dihydroxy -2 , 4-dimethoxy-phenanthryl relates to a pharmaceutical composition and a health food composition having a variety of cancer-cell proliferation inhibitory activity as an active ingredient to the Trenton, 6,7-dihydroxy-2,4-dimethoxy-phenanthrene according to the invention (6,7-dihydroxy-2,4-dimethoxy phenanthrene) is price, not normal cells, cancer cells derived from mouse MC3T3-E1 (osteoblast precursor cells, osteoblasts) and adipocyte 3T3-L1 (preadipocytes) cell line has an almost toxic indicate if the books, uterine cancer cells (HeLa), lung cancer cells (HepG2), and the growth of colon cancer cells (HCT-116) 10 ~ 40 ug / mL of can be effectively inhibited at low concentrations. Also appears to confirm the activation of such a cancer cell growth through inhibition of NAG-1, known as the anti-cancer gene, it can be expected to inhibit cancer cell growth effects and cancer inhibitory effect of the conventional known phytochemicals.본 발명은 생마의 주아(영여자)로부터 유래된 6,7-디하이드록시-2,4-디메톡시 페난트렌을 유효성분으로 함유하여 다양한 암세포 증식억제 활성을 갖는 약학 조성물 및 건강식품 조성물에 관한 것으로, 본 발명에 따른 6,7-디하이드록시-2,4-디메톡시 페난트렌(6,7-dihydroxy-2,4-dimethoxy phenanthrene)은 암세포주가 아닌 정상 세포 유래의 마우스 MC3T3-E1 (조골 전구세포, 골아세포) 및 지방세포 3T3-L1 (지방 전구세포) 세포주에는 거의 독성을 나타내지 않으면서, 자궁암 세포 (HeLa), 간암세포 (HepG2) 및 대장암 세포 (HCT-116)의 생육을 10~40 ug/mL의 낮은 농도에서 효율적으로 억제할 수 있다. 또한 이러한 암 세포 성장억제는 항암 유전자로 알려진 NAG-1의 활성화를 통해 나타남을 확인하여, 기존의 알려진 파이토케미컬의 암세포 생육 억제 효과 및 암 발생 억제효과를 기대할 수 있다.
