An electrosurgical instrument can selectively provide electrosurgical energy to an energizable electrode. The instrument can include an interface configured to issue one or more waveform command signals corresponding to a selected therapeutic result waveform generation circuitry configured to deliver in response to the one or more wave form command signals, a corresponding one or more waveforms selected from a first, a second, and a third waveform, each of the first, second and third waveforms being different from the other of the first, second and third waveforms. The instrument can include a variable output voltage supply configured to supply a selected electrical current to a corresponding output, and an output driver circuitry configured to combine at least one or more of the waveforms with the respective high-voltage electrical current to generate an electrosurgical current suitable for achieving the therapeutic result when applied to a treatment site by the energizeable electrode.