GEORG JAESCHKE,LOTHAR LINDEMANN,HEINZ STADLER,ERIC VIEIRA
申请号：
PT13735315
公开号：
PT2875000T
申请日:
2013.07.12
申请国别(地区):
PT
年份:
2016
代理人:
摘要：
The present invention relates to ethynyl derivatives of formula I wherein R1 is phenyl, which is optionally substituted by 1-2 halogen atoms； selected from fluorine or chlorine； or to a pharmaceutically acceptable acid addition salt in enantiomerically pure form. It has been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
