JAESCHKE, GEORG,LINDEMANN, LOTHAR,STADLER, HEINZ,VIEIRA, ERIC
申请号：
PH12014502695
公开号：
PH12014502695B1
申请日:
2014.12.03
申请国别(地区):
PH
年份:
2015
代理人:
摘要：
The present invention relates to ethynyl derivatives of formula (I) wherein R1 is phenyl, which is optionally substituted by 1-2 halogen atoms； selected from fluorine or chlorine； or to a pharmaceutically acceptable acid addition salt in enantiomerically pure form. It has been found that the compounds of general formula (I) are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
