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DERIVATI ARILETINILA
专利权人:
F. Hoffmann - La Roche AG
发明人:
Jaeschke, Georg,Lindemann, Lothar,Stadler, Heniz,Vieira, Eric
申请号:
HRP20161691
公开号:
HRP20161691T1
申请日:
2016.12.12
申请国别(地区):
HR
年份:
2017
代理人:
摘要:
The present invention relates to ethynyl derivatives of formula I wherein R1 is phenyl, which is optionally substituted by 1-2 halogen atoms; selected from fluorine or chlorine; or to a pharmaceutically acceptable acid addition salt in enantiomerically pure form. It has been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
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中国工程科技知识中心
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