PROBLEM TO BE SOLVED: To provide a pharmaceutical agent for prevention and treatment of articular rheumatism, psoriasis, osteoarthritis, asthma, atherosclerosis, Parkinsons disease, Alzheimers disease, ischemia-reperfusion injury, and periodontitis.SOLUTION: An MK2 coupling inhibitor contains a compound represented by the following general formula (1), its salt or their solvate as an active component. In general formula (1), R1 and R4 represent a hydrogen atom, a halogen atom, a hydroxyl group, or a C1-3 alkyl group, R2 and R3 each independently represent a hydrogen atom, a hydroxyl group, or a C1-3 alkyl group, and R5, R6, R7, and R8 each independently represent a hydrogen atom, a hydroxyl group, a halogen atom, or a C1-3 alkyl group.COPYRIGHT: (C)2014,JPO&INPIT【課題】MK2を阻害し、関節リウマチ、乾癬、変形性関節症、喘息、アテローム性動脈硬化症、パーキンソン病、アルツハイマー症、虚血再還流障害、歯周炎の予防及び治療のための薬剤の提供。【解決手段】次の一般式(1)で表される化合物、若しくはその塩、又はそれらの溶媒和物を有効成分とするMK2阻害剤。[式中、R1及びR4は、水素原子、ハロゲン原子、水酸基又はC1-3アルキル基を示し、R2及びR3は、それぞれ独立して、水素原子、水酸基又はC1-3アルキル基を示し、R5,R6,R7及びR8は、それぞれ独立して、水素原子、水酸基、ハロゲン原子又はC1-3アルキル基を示す]【選択図】なし
