Combines the PPARγ activation effect and angiotensin II receptor antagonistic activity, and is useful as an agent for preventing and / or treating hypertension, metabolic syndrome, etc., represented by the following general formula (I) the present invention, α- phenoxy-benzeneacetic acid solvate thereof, and to pharmaceutical compositions containing the same or a salt thereof or derivatives. [The following formula, (III) Q is below or (II): [wherein, column indicates a C 1-6 alkyl group, 2, R 2 R 1, R 1 R is a substituted or unsubstituted denotes a C 1-6 alkyl group and R 3, unsubstituted C 1-6 alkyl group, a hydrogen atom, or a substituted, or the following (IV): [(IV) wherein, X, Y represents an N or CH, R 4 is substituted C 1-6 alkyl group shows Z is a 1-6 alkylene chain such as C, R 11 represents a hydrogen atom, a C 6-10 aryl group, m is an] represents 0 or 1 Indicates] indicates a are each independently, 5,R 6 R represents a C 1-6 alkyl group represents a carboxyl group, and 8, R 9, R 10 R, R 7 is independently , represents a hydrogen atom, a halogen atom or the like n is an integer of 1 to 3]本発明は、アンジオテンシンII受容体拮抗作用及びPPARγ活性化作用を併せ持ち、高血圧症、メタボリックシンドローム等の予防及び/又は治療剤として有用な、下記一般式(I)で表されるα-フェノキシベンゼン酢酸誘導体若しくはその塩又はそれらの溶媒和物、及びそれを含有する医薬組成物に関する。〔下記式中、Qは、下記(II)又は(III):[式中、R1、R1’は、C1-6アルキル基を示し、R2、R2’は、置換又は無置換C1-6アルキル基を示し、R3は、水素原子、置換又は無置換C1-6アルキル基、又は下記(IV):[(IV)式中、X、YはCH又はNを示し、ZはC1-6アルキレン鎖等を示し、R11は水素原子、C6-10アリール基等を示し、mは0又は1を示す]を示し;R4は、置換C1-6アルキル基を示す]を示し;R5、R6はそれぞれ独立して、C1-6アルキル基を示し、R7は、カルボキシル基等を示し、R8、R9、R10は、それぞれ独立して、水素原子、ハロゲン原子等を示し;nは1~3の整数を示す〕
