您的位置: 首页 > 农业专利 > 详情页

Tunable endogenous protein degradation
专利权人:
Inc.;Dana-Farber Cancer Institute
发明人:
Buckley, Dennis,Winter, Georg,Phillips, Andrew J.,Heffernan, Timothy,Bradner, James,Roberts, Justin,Nabet, Behnam
申请号:
AU2016301196
公开号:
AU2016301196A1
申请日:
2016.08.08
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
The present invention provides a means to modulate gene expression in vivo in a manner that avoids problems associated with CRISPR endogenous protein knock-out or knock-in strategies and strategies that provide for correction, or alteration, of single nucleotides. The invention includes inserting into the genome a nucleotide encoding a heterobifunctional compound targeting protein (dTAG) in-frame with the nucleotide sequence of a gene encoding an endogenously expressed protein of interest which, upon expression, produces an endogenous protein-dTAG hybrid protein. This allows for targeted protein degradation of the dTAG and the fused endogenous protein using a heterobifunctional compound.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充