MURPHY, Andrew J.,THURSTON, O. Gavin,VARGHESE, Bindu,GURER, Cagan
申请号：
DK14781783
公开号：
DK2922394T3
申请日:
2014.09.23
申请国别(地区):
DK
年份:
2017
代理人:
摘要：
Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRP± gene. Genetically modified mice are described, including mice that express a human or humanized SIRP± protein from an endogenous SIRP± locus.
