ВУ Ченбин (CN),АМБРОЗИ Доминик Дж. (US),СИЕХ Чун-Мин (US),ГХАЮР Тарик (US)
申请号：
RU2012154210/10
公开号：
RU2012154210A
申请日:
2011.05.13
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A binding protein containing the first and second polypeptide chains, where the specified first polypeptide chain contains the first VD1- (X1) n-VD2-C- (X2) n, where: VD1 represents the first variable domain of the heavy chain； VD2 represents the second the variable domain of the heavy chain； C is a constant domain of the heavy chain； X1 is a linker provided that it is not CH1； X2 is an Fc region； and n independently represents 0 or 1； wherein said second polypeptide chain contains a second VD1- (X1) n-VD2-C- (X2) n, where: VD1 is the first variable domain of the light chain； VD2 is the second variable domain of the light chain； C is a constant domain of the light chain ； X1 is a linker provided that it is not CH1； X2 does not contain an Fc region； and independently represents 0 or 1； where in said first polypeptide chain VD1 contains an amino acid sequence selected from the group consisting of SEQ ID NO: 60-148, 196, 198, 200, 202, 204, 206, 208 and 210； and VD2 contains an amino acid sequence selected from the group consisting of SEQ ID NO: 213 and 227； where in said second polypeptide chain VD1 contains an amino acid sequence selected from the group consisting of SEQ ID NO: 149-189, 197, 199, 201 , 203, 205, 207, 209 and 211； and VD2 contains an amino acid sequence selected from the group consisting of SEQ ID NO: 216 and 229； where the binding protein binds human IL-1β and human IL-1α. 2. A binding protein containing the first and second polypeptide chains, wherein said first polypeptide chain contains the first VD1- (X1) n-VD2-C- (X2) n, where: VD1 is the first variable domain of the heavy chain； VD2 is the second variable1. Связывающий белок, содержащий первую и вторую полипептидные цепи, где указанная первая полипептидная цепь содержит первый VD1-(X1)n-VD2-C-(X2)n, где:VD1 представляет собой первый вариабельный домен тяжелой цепи；VD2 представляет собой второй вариабельный домен тяжелой цепи；C представляет собой константный домен тяжелой цепи；X1 представляет
