A disposable medical sharp instrument storage box includes a box body, a box cover, a flip cover and an anti-opening structure. The box body has a box opening; the box cover seals the box opening and is provided with a waste hole; the flip cover and the box cover are connected to each other, and the flip cover is closed on the box cover, so that the waste hole is covered between the flip cover and the box cover; The anti-opening structure includes a first structural member and a second structural member. The first structural member and the second structural member are respectively provided on the clamshell and the box cover. The clamshell is assembled by preventing the first structural member and the second structural member from coming off. Prevent being opened. Thereby, by using the anti-opening structure to buckle the clamshell on the box cover, the effect of preventing the clamshell from being deliberately opened or being opened by mistake can be achieved.一種拋棄式醫療銳器收納盒,包括:盒體、盒蓋、掀蓋以及防開結構。盒體具有盒開口;盒蓋封蓋盒開口且設有廢棄孔;掀蓋與盒蓋彼此連接,且掀蓋蓋合於盒蓋,使廢棄孔被包覆於掀蓋與盒蓋之間;防開結構包含第一結構件和第二結構件,第一結構件和第二結構件分別設於掀蓋和盒蓋,掀蓋經由將第一結構件和第二結構件彼此防脫結合而防止被掀開。藉此,利用防開結構將掀蓋扣死於盒蓋上,可達成防止掀蓋被蓄意開啟或被誤開啟的效果。