A medicine box including a casing with a mouth, and a box cover. One or more sides of the mouth are set with resilient snaps and one or more sides of the box cover have conjunction holes. One side of the box cover has a medicine hole, the medicine hole is blocked by the cover when in a sealed position. To remove medicine from the casing, the resilient snap is pressed to separate from the conjunction hole. The box cover can then freely slide up and down the mouth to expose the medicine hole and remove medicine from the medicine box. After taking out the medicine, the box cover may slide downward to buckle the resilient snap into the conjunction hole, firmly fixing the box cover on the mouth.
