Deuterated Alpha5 subunit-selective Negative Allosteric Modulators of Gamma-Aminobutyric Acid Type A Receptors as Fast Acting Treatment for Depression and Mood Disorders
UNIVERSITY OF MARYLAND, BALTIMORE;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC
发明人:
Scott Thompson,Adam Van Dyke,Craig Thomas,Patrick Morris
申请号：
US16642445
公开号：
US20200199119A1
申请日:
2018.08.28
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to novel alpha5 subunit-selective negative allosteric modulators of GABAA receptors that have been deuterated to improve their medicinal properties by prolonging their half-lives, rendering them useful as fast-acting pharmaceutical treatments for depression related disorders.
