METHODS FOR THE SYNTHESIS OF 13C LABELED DHA AND USE AS A REFERENCE STANDARD

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专利权人:

发明人:

M. Amin Khan,Paul L. Wood,Dayan Goodenowe

申请号：

US14359097

公开号：

US20140336397A1

申请日:

2012.11.16

申请国别(地区):

US

年份:

2014

代理人:

摘要：

A method for preparing 13C labeled docosahexaenoic acid (DHA) represented by Formula A: The method comprises the conversion of 2-pentyn-1-ol to 13C labeled DHA by reaction with propargyl alcohol, 13C labeled propargyl alcohol and methyl pent-4-ynoate. The various steps involved include tosylation, coupling, bromination, selective hydrogenation and ester hydrolysis to obtain the final product.

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