MANLEY, PAUL W.,MARTINY-BARON, GEORG,MESTAN, JUERGEN
申请号：
ES06706432
公开号：
ES2373912T3
申请日:
2006.01.26
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Use of a pyrimidylaminobenzamide compound of formula I, or an N-oxide or a pharmaceutically acceptable salt thereof, wherein the pyrimidylaminobenzamide of formula I has the following structure: wherein R 1 represents hydrogen, lower alkyl, lower alkoxy (lower) -alkyl (lower), acyloxy-alkyl (lower), carboxyalkyl (lower), alkoxy (lower) -carbonyl-alkyl (lower) or phenyl-alkyl (lower)； R2 represents hydrogen, lower alkyl, optionally substituted with one or more identical or different R3 radicals, cycloalkyl, benzcycloalkyl, heterocyclyl, an aryl group, or a mono- or bicyclic heteroaryl group comprising zero, one, two or three nitrogen atoms of ring and zero or an oxygen atom and zero or a sulfur atom, groups that in each case are not substituted or are mono- or polysubstituted； and R3 represents hydroxy, lower alkoxy, acyloxy, carboxy, lower alkoxycarbonyl, carbamoyl, N-mono- or N-disubstituted carbamoyl, amino, mono- or disubstituted amino, cycloalkyl, heterocyclyl, an aryl group, or a group mono- or bicyclic heteroaryl comprising zero, one, two or three ring and zero nitrogen atoms or an oxygen and zero atom or a sulfur atom, groups that in each case are not substituted or are mono- or polysubstituted； or wherein R1 and R2 together represent alkylene with four, five or six carbon atoms optionally mono- or disubstituted with lower alkyl, cycloalkyl, heterocyclyl, phenyl, hydroxy, lower alkoxy, amino, mono- or disubstituted amino, oxo, pyridyl , pyrazinyl or pyrimidinyl； benzalkylene with four or five carbon atoms； oxaalkylene with one oxygen and three or four carbon atoms； or azaalkylene with one nitrogen and three or four carbon atoms in which the nitrogen is not substituted or is substituted with lower alkyl, phenylalkyl (lower), alkoxy (lower) -carbonyl-alkyl (lower), carboxy-alkyl (lower) , carbamoyl-lower alkyl, carbamoyl (N-mono- or N, N-disubstituted) -alkyl (lower), cycloalkyl, lower alkoxycarbonyl, carboxy, phenyl, substituted phenyl, pyridinyl, pyrimidinyl,
