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Tetrazole derivatives
专利权人:
Hoffmann-La Roche Inc.
发明人:
Marius Hoener,Juergen Wichmann
申请号:
US15569349
公开号:
US10577332B2
申请日:
2016.04.19
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention relates to compounds of formula IwhereinR1′; is CH3 R1 is methyl, ethyl, CF3, CH2OH, cyclopropyl or cyano, or R1′; and R1 may form together a 1,1-dioxo-tetrahydro-thiophen-3-yl ring;R2 is hydrogen, methyl, ethyl, isopropyl, tertbutyl, cyclopropyl or CF3;R3 is Cl, F, CF3, methyl, methoxy, isopropyl or cyclopropyl;R4 is hydrogen, methyl, F or Cl;or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof for use in the treatment of schizophrenia, bipolar disorder, obsessive-compulsive disorder or autism spectrum disorder.
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