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Imidazole derivatives
专利权人:
Hoffmann-La Roche Inc.
发明人:
Marius Hoener,Juergen Wichmann
申请号:
US15830399
公开号:
US10029989B2
申请日:
2017.12.04
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention relates to compounds of formula IwhereinR1′ is CH3;R1 is methyl, ethyl, CF3, cyclopropyl, CH2OH or R1′ and R1 may form together with the carbon atom to which they are attached a 1,1-dioxo-thiolan-3-yl ring;R2 is hydrogen, methyl, ethyl, isopropyl, tertbutyl, cyclopropyl, CH2OH or C(CH3)2OH;R3 is Cl, F, CF3, cyano, methyl or cyclopropyl;R4 is hydrogen, methyl or F;or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof for use in the treatment of psychiatric disorders such as schizophrenia, bipolar disorder, obsessive-compulsive disorder or autism spectrum disorder.
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