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Imidazole derivatives
专利权人:
发明人:
Marius Hoener,Juergen Wichmann
申请号:
US15866444
公开号:
US10092546B2
申请日:
2018.01.09
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention relates to compounds of formula IwhereinR1′ is CH3R1 is methyl, ethyl, CF3, CH2OH, cyclopropyl or cyano, or R1′ and R1 may form together a 1,1-dioxo-tetrahydro-thiophen-3-yl ringR2 is hydrogen, methyl, ethyl, isopropyl, tertbutyl, cyclopropyl, hydroxmethyl, or 2-propyl-2-olR3 is Cl, F, CF3, methyl, methoxy, isopropyl, cyano or cyclopropylR4 is hydrogen, methyl, F or Clor to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof.The compounds of formula I may be used in the treatment of psychiatric disorders such as schizophrenia, bipolar disorder, obsessive-compulsive disorder or autism spectrum disorder.
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