ISOLATION OF ATRARIC ACID, SYNTHESIS OF ATRARIC ACID DERIVATIVES, AND USE OF ATRARIC ACID AND THE DERIVATIVES THEREOF FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA, PROSTATE CARCINOMA AND SPINOBULBAR MUSCULAR ATROPHY
PROBLEM TO BE SOLVED: To provide a method for isolating atraric acid from biological material, atraric acid derivatives, the chemical synthesis thereof, and the use of atraric acid and the derivatives thereof for the treatment of or the production of a medicament for treating benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy. SOLUTION: The biomaterial is a bark of African plum tree P. africana, or lichenes viable on the bark of the P. africana. Stirring of the atraric acid in the chemical synthesis is performed in a primary aliphatic alcohol solution together with an equimolar amount of alkali hydroxide or alkaline earth hydroxide. The atraric acid is used as a basic substance for development of the other agents used for the treatment of the benign prostatic hyperplasia, prostate malignant tumor, or spinobulbar muscular atrophy. COPYRIGHT: (C)2013,JPO&INPIT
