Vogel, Jens,Giovannini, Roberto,Konstantinov, Konstantin B.,Nguyen, Huong,Wu, Peng
申请号：
AU2011203578
公开号：
AU2011203578B2
申请日:
2011.07.14
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2011203578B220121011.pdf#####ABSTRACT The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration.
