LIN, ShiXian,YANG, XiaoYu,TOSTE, F. Dean,CHANG, Christopher J.
申请号：
EP17870337
公开号：
EP3538087A4
申请日:
2017.11.13
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Chemoselective conjugation is achieved through redox reactivity by reacting an N-transfer oxidant with a thioether substrate in a redox reaction in an aqueous environment to form a conjugation product. In embodiments, Redox-Activated Chemical Tagging (ReACT) strategies for methionine-based protein functionalization. Oxaziridine (Ox) compounds serve as oxidant-mediated reagents for direct functionalization by converting methionine to the corresponding sulfimide conjugation product.
