JASON ALLAN WILES,AVINASH S. PHADKE,MILIND DESHPANDE,ATUL AGARWAL,XIANGZHU WANG,DAWEI CHEN,AKIHIRO HASHIMOTO,GODWIN PAIS,VENKAT RAO GADHACHANDA,QIUPING WANG
申请号：
ARP160102593
公开号：
AR106018A1
申请日:
2016.08.24
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
1. The application relates to a compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein: Q1 es C (R1 ')；Q es C (R R)Q3 is C (R3 m3 is')；X1 is n, X2 is ch, R1,R1',R2,R2',R³ and R³ 'are independently selected from hydrogen, halogen, hydroxyl, nitro, cyano, amino, C₁₋₆alkyl, C₂₋₆alkenyl, C₁₋₆alkoxy, C₂₋₆alquinyl, C₂₋₆alkanoyl, C₁₋₆thioalkyl, -C (O) OR⁹ ,-OC (O) R-8313； (c) (o) r830404,-C (o) No. 8313； r83044,-OC (O) NR R-No. 8313； - C (o) or 830404；C₁₋₂haloalkyl, and C₁₋₂haloalkoxy； R⁹ and R¹⁰ are independently selected, each time they appear, from hydrogen, C₁₋₆alkyl, (C₃₋₇cycloalkyl) C₀₋₄alkyl, -C₀₋₄alkyl (C₃₋₇cycloalkyl),y -O-C alquil (C cicloalquilo)O r 1 and R 2 combine to form three carbon periodic rings； or R 2 and R 3 combine to form three to six carbon periodic rings； a is a group selected from formula compounds (3) and (4)；R83099 and r8310e from - CHO, - C (o) n8322；-C (O) NH (CH)C₂₋₆alkanoyl, hydrogen, hydroxyl, halogen, cyano, nitro, -COOH, -SO₂NH₂,vinyl, C₁₋₆alkyl, C₂₋₆alkenyl, C₁₋₆alkoxy, -C₀₋₄alkyl (C₃₋₇cycloalkyl),-C (O) C alquil (C cicloalquilo)-P (O) (OR)-OC (O) R-C (O) OR-C (O) N (CH CH R) (R)-8313； (c) (o) r830404,phenyl, and 5-6 membered heteroaryl； R⁸ and R⁸ ’are independently selected from hydrogen, halogen, hydroxyl, C₁₋₆alkyl, -C₀₋₄alkyl (C₃₋₇cycloalkyl),C₁₋₆alkoxy, and (C₁₋₄alkylamino) C₀₋₂alkyl； or R⁸ and R⁸ ’are taken together to form an oxo group； or R⁸ and R⁸ ’can be taken together with the carbon atom to which they are attached to form a 3-membered carbocyclic ring； X¹¹ is N or CR¹¹；X1 is CR1；X13 is Cr13；X es N o CROne R1 and R3 are selected from R3 1,The other R2 and R3 were selected from 3:2；R³¹ is selected from hydrogen, halogen, hydroxyl, nitro, cyano, amino, -COOH, C₁₋₂haloalkyl, C₁₋₂haloalkoxy, C₁₋₆alkyl, -C₀₋₄alkyl (C₃₋₇cycloalkyl),Cquealkenyl, C₂₋₆alkanoyl, C₁₋₆alkoxy, C₂₋₆alkenyloxy, -C (O) OR⁹,C tioalquilo -C alquilo-NR R-C (o) No. 8313； r83044,-SO₂R⁹,-So8322； - No. 8313； - r83044；-OC (O) Ry -C (NR) NR Rwh
