The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.本發明係關於針對或特異性結合於趨化細胞素受體CXCR2之多肽,且詳言之關於能夠調節來自CXCR2之信號轉導的多肽。本發明亦關於能夠表現本發明多肽的核酸、載體及宿主細胞,包含該等多肽之醫藥組合物,及以該等多肽及組合物於治療涉及CXCR2功能異常之疾病的用途。
