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WT1抗原胜肽結合疫苗
专利权人:
INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY, INC.;SUMITOMO DAINIPPON PHARMA CO., LTD.
发明人:
LI, CHIANG JIA,李嘉强,李嘉強,BAN, HITOSHI,阪仁志,NISHIO, YUKIHIRO,西尾幸博,GOTO, MASASHI,後藤正志,NISHIHARA, NORIO,西原纪夫,西原紀夫
申请号:
TW103111843
公开号:
TW201505650A
申请日:
2014.03.28
申请国别(地区):
TW
年份:
2015
代理人:
摘要:
The present invention provides a compound expressed by formula (1) or a salt, etc., thereof. In formula (1): Xa and Ya represent single bonds, etc.; a cancer antigen peptide (A) represents an MHC class I-restrictive WT1 peptide comprising a 7-30 residue amino acid; R1 represents a hydrogen atom, a group expressed by formula (2) (in the formula, Xb and Yb represent single bonds, etc., and a cancer antigen peptide (B) represents an MHC class I-restrictive WT1 peptide comprising a 7-30 residue amino acid and having a different sequence to that of the cancer antigen peptide (A)), or a cancer antigen peptide (C); and a cancer antigen peptide (C) represents an MHC class I-restrictive WT1 peptide or an MHC class II-restrictive WT1 peptide that comprise a 7-30 residue amino acid which contains one cysteine residue, and have a different sequence to that of the cancer antigen peptide (A).本發明提供式(1)所表示之化合物或其鹽等:[式中,Xa及Ya表示單鍵等,癌抗原胜肽A表示包含7~30殘基之胺基酸的MHC I類限制性WT1胜肽,R1表示氫原子、式(2)所表示之基、或癌抗原胜肽C:(式中,Xb及Yb表示單鍵等,癌抗原胜肽B表示序列與癌抗原胜肽A不同且包含7~30殘基之胺基酸的MHC I類限制性WT1胜肽),癌抗原胜肽C表示序列與癌抗原胜肽A不同且包含包括1個半胱胺酸殘基之7~30殘基之胺基酸的MHC I類限制性WT1胜肽或MHC II類限制性WT1胜肽]。
来源网站:
中国工程科技知识中心
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