PROBLEM TO BE SOLVED: To provide an antidementia agent which is free from the problem of side effects and is excellent in safety and an agent for improving learning and memory which is useful for improvement of learning and memory and can be ingested continuously.SOLUTION: It is discovered that 2,5-piperazinedione, 3,6-bis(phenylmethyl)-, (3R, 6S)-(9Cl) found in a food has SERT binding inhibitory activity, enhances a serotonin concentration of prefrontal area and has antidepressant activity. Further since inhibiting acetylcholine degrading enzyme activity, increasing an acetylcholine concentration in hippocampus with deepest reference to learning and memory and raising a percentage of correct answers of a radial maze test using a scopolamine-induced learning disorder rat used widely as a dementia animal model, 2,5-piperazinedione, 3,6-bis(phenylmethyl)-, (3R, 6S)-(9Cl) has learning and memory improving action.COPYRIGHT: (C)2013,JPO&INPIT【課題】副作用の問題のない、安全性に優れた抗認知症剤、また、学習記憶の改善に有用で、継続的摂取可能な学習記憶改善剤を提供する。【解決手段】食品中から見出した2,5-ピペラジンジオン,3,6-ビス(フェニルメチル)-,(3R,6S)-(9Cl)が、SERT結合阻害活性を持ち、前頭前野のセロトニン濃度を上昇させ、抗うつ作用があることを発見した。さらに、2,5-ピペラジンジオン,3,6-ビス(フェニルメチル)-,(3R,6S)-(9Cl)がアセチルコリン分解酵素活性を阻害し、学習記憶に最も関連の深い海馬におけるアセチルコリン濃度を増やし、認知症動物モデルとして汎用されているスコポラミン誘発学習障害ラット用いた放射状迷路試験の正答率を上昇させることから、学習記憶改善作用を併せ持つ。【選択図】なし
