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促進抗原消除的抗原結合分子
专利权人:
CHUGAI SEIYAKU KABUSHIKI KAISHA;中外制藥株式會社
发明人:
井川智之,前田敦彥,原谷健太,岩柳有起,橘達彥
申请号:
HK18112157
公开号:
HK1252829A1
申请日:
2014.12.01
申请国别(地区):
HK
年份:
2019
代理人:
摘要:
The present inventors created antigen-binding molecules containing an antigen-binding domain and an Fc³-receptor-binding domain, wherein the molecules have human-FcRn-binding activity in an acidic pH range condition, the antigen-binding domain changes the antigen-binding activity of the antigen-binding molecules depending on the ion-concentration condition, and the Fc³ receptor-binding domain has higher binding activity to the Fc³ receptor in a neutral pH range condition than an Fc region of a native human IgG in which the sugar chain bound at position 297 (EU numbering) is a fucose-containing sugar chain.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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