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Antigen-binding molecules that promote the disappearance of antigens with multiple physiological activities
专利权人:
中外製薬株式会社
发明人:
井川 智之,前田 敦彦,丹波 茂郎,北澤 剛久,馬場 威,類家 慶直,根津 淳一
申请号:
JP2013536425
公开号:
JP6322411B2
申请日:
2012.09.28
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
The present inventors newly discovered that even if an antigen-binding molecule inhibits in vitro some of the physiological activities of an antigen having two or more physiological activities without inhibiting the remaining physiological activities, the molecule can promote elimination of the antigen from blood (from serum or plasma) and as a result reduce the physiological activities in vivo, when the antigen-binding molecule is conferred with the properties: (i) of binding to human FcRn under an acidic pH range condition; (ii) of binding under a neutral pH range condition to human Fc receptor stronger than native human IgG, and (iii) that its antigen-binding activity alters according to the ion concentration.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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