A method for the preparation of a nicotine-cellulose combination, the method comprising simultaneous loading of the nicotine on the cellulose and agglomeration of the particles so as to obtain a suitably loaded combination with a mean particle size that is suitable for use e.g. in snuff compositions packed in pouches of gauze or other materials with opening. The invention further relates to the use of such a nicotine-cellulose combination for the preparation of a snuff composition for achievement of a fast onset of action of nicotine after application of the snuff composition to the oral cavity of a subject, wherein the composition has a high release rate so that when subjected to an in vitro dissolution test about 45% or more of the total content of nicotine is released within 30 minutes. Moreover, the invention relates to an improved snuff composition for application to the oral cavity.
