The present invention aims to provide an economical manufacturing method of a patch preparation that decreases the manufacturing loss, and a manufacturing method of a patch preparation that can provide a patch preparation which has a sufficiently high skin permeation amount of a drug even without increasing the area and thickness of an adhesive layer, wherein precipitation of crystal of the drug is extremely difficult.A method of manufacturing a patch preparation 1 comprising:pouring a composition for forming an adhesive layer into a container 11 having a concave part 12 with a shape corresponding to a patch preparation to be manufactured, wherein the composition contains a drug, an adhesive polymer and an organic solventremoving the organic solvent from the composition through drying to form a drug-containing adhesive layer 3 in the concave part 12 andlaminating a support 2 on the drug-containing adhesive layer 3 to give the patch preparation 1 comprising the support 2 and the drug-containing adhesive layer 3 formed on one surface of the support 2.
