KELLY, Michael G.,KINCAID, John,FANG, Yunfeng,CAO, Yeyu,KAUB, Carl,GOWLUGARI, Sumithra
申请号：
ES07753320
公开号：
ES2596532T3
申请日:
2007.03.16
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A bicycloheteroaryl compound according to formula II, III or IV: ** Formula ** in which W, Z are CH； L1 is a substituted or unsubstituted, SO, SO2 or C1-C5 alkylene bond； R1 is selected from a substituted or unsubstituted aryl； each of R2 and R2 "is independently selected from hydrogen, halo, and substituted or unsubstituted C1-C6 alkyl； or any of R2 'and R2" are joined to form a 3-7 atom cycloalkyl or cycloheteroalkyl ring； R3 is selected from hydrogen, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted bicycloaryl, and substituted or unsubstituted bicycloheteroaryl, - OH, -NH2 and -NH-R59a, and in which R59a is alkyl, cycloalkyl, acyl, aryl or heteroaryl； R5 is independently selected from H, alkyl, substituted alkyl, acyl, substituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl, substituted or unsubstituted alkylamino substitute, substituted arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl, substituted or unsubstituted sulfoxide, substituted or unsubstituted sulfone, substituted or unsubstituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted arylsulfonyl, sulfuric acid, ester of sulfuric acid, substituted or unsubstituted dihydroxyphosphoryl, substituted or unsubstituted aminodihydroxyphosphoryl, azido, carboxy, substituted or unsubstituted carbamoyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted dialkylamino, halo, heteroaryloxy, heteroaryl sus substituted or unsubstituted, substituted or unsubstituted heteroalkyl, hydroxy, nitro and thio； or a pharmaceutically acceptable salt or solva
