ß2GPI GENE EXPRESSION-SUPPRESSING NUCLEIC ACID CONJUGATE

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专利权人:

发明人:

Kazutaka NAGATOMO,Kazuhiro MASUDA,Minako KANDA,Yoji YAMADA,Hiroto IWAI,Asana MAKINO,Shintaro HOSOE,Takeshi KUBOYAMA,Keiji UEHARA,Yasuhiro SUZUKI

申请号：

US15740090

公开号：

US20180193471A1

申请日:

2016.07.15

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention provides a nucleic acid conjugate comprising: a double-stranded nucleic acid consisting of a sense strand and an antisense strand and comprising a duplex region of at least 11 base pairs and a ligand part, wherein an oligonucleotide with a strand length of 17 to 30 nucleotides in the antisense strand is complementary to a target β2GPI mRNA sequence, and the 3′ end or 5′ end of the sense strand has a ligand part represented by following formula (I), formula (II), formula (III), formula (IV) or formula (V).

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