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Compositions and Methods for Inhibiting Expression of the PCSK9 Gene
专利权人:
Alnylam Pharmaceuticals; Inc.
发明人:
Pamela Tan,Birgit Bramlage,Maria Frank-Kamenetsky,Kevin Fitzgerald,Akin Akinc,Victor E. Kotelianski
申请号:
US15807275
公开号:
US20180216115A1
申请日:
2017.11.08
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier and method for treating diseases caused by PCSK9 gene expression.
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