COMPLEXE D'ACIDE NUCLÉIQUE INHIBANT L'EXPRESSION DU GÈNE BÉTA2GPI

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专利权人:

Kyowa Hakko Kirin Co.; Ltd.

发明人:

申请号：

EP16824555.3

公开号：

EP3323893A4

申请日:

2016.07.15

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

The present invention provides a nucleic acid conjugate comprising: a double-stranded nucleic acid consisting of a sense strand and an antisense strand and comprising a duplex region of at least 11 base pairs； and a ligand part, wherein an oligonucleotide with a strand length of 17 to 30 nucleotides in the antisense strand is complementary to a target ²2GPI mRNA sequence, and the 3' end or 5' end of the sense strand has a ligand part represented by following formula (I), formula (II), formula (III), formula (IV) or formula (V).

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