Computer aided visualization and diagnosis by volume analysis of optical coherence tomography (OCT) angiographic data. In one embodiment, such analysis comprises acquiring an OCT dataset using a processor in conjunction with an imaging system； evaluating the dataset, with the processor, for flow information using amplitude or phase information； generating a matrix of voxel values, with the processor, representing flow occurring in vessels in the volume of tissue； performing volume rendering of these values, the volume rendering comprising deriving three dimensional position and vector information of the vessels with the processor； displaying the volume rendering information on a computer monitor； and assessing the vascularity, vascular density, and vascular flow parameters as derived from the volume rendered images.
