The present invention relates to compositions and methods for treating Staphylococcus aureus (S. aureus) infections. In particular, the present invention provides vaccines comprising a Panton-Valentine Leukocidin (PVL) antigen, antibodies which bind a PVL antigen and compositions containing the same, methods of making such compositions and methods for treating S. aureus infections, including those that are community acquired methicillin-resistant infections. The present invention also provides PVL antibodies, including PVL antibodies specific for a single PVL subunit, and PVL antigens, including conjugated and mutated PVL antigens.本發明係關於治療金黃色葡萄球菌(Staphylococcus aureus(S.aureus))感染之組合物及方法。詳言之，本發明提供包含一殺白血球素(Panton－Valentine Leukocidin)(PVL)抗原之疫苗、結合一PVL抗原之抗體及含有彼等之組合物，製備該等組合物之方法及治療金黃色葡萄球菌感染(包括社區獲得性抗二甲氧苯青黴素感染者)之方法。本發明亦提供PVL抗體，其包括對單一PVL次單位具有特異性之PVL抗體；及PVL抗原，其包括共軛及突變之PVL抗原。
