Brian H. White,Rossitza G. Alargova,Patrick Rosaire Bazinet,Craig A. Dunbar,Patrick Lim Soo,Rajesh R. Shinde,Mark T. Bilodeau,Sudhakar Kadiyala,Richard Wooster,Timothy Barder,Kerry Whalen,James Giffor
申请号：
US15319738
公开号：
US20170151339A1
申请日:
2015.06.30
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, comprising conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
