Rajesh R. Shinde,Mark T. Bilodeau,Richard Wooster,Sudhakar Kadiyala
申请号：
US16625368
公开号：
US20200237746A1
申请日:
2018.06.19
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to an HSP90 targeting moiety via a linker have been designed. Nanoparticles and microparticles comprising such conjugates can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or other diseases.
