A medicament delivery device includes a body having a proximal end and a distal end in turn comprising a distal housing part (10) and a medicament container holder (80) adapted to receive a medicament container; a dose setting drum (40) for setting a dose when rotated in a first direction and for delivering a dose when rotated in a second direction and a hollow drive drum sleeve (30) selectively operably connectable to a hollow piston plunger (20) for delivering a dose.