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INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)
专利权人:
发明人:
申请号:
EP17746235.5
公开号:
EP3484871A1
申请日:
2017.13.07
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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