SOONG KIM,JENNIFER X. HOON - QIAO,GEORGE O. TORA,JOHN LLOYD,JAMES A. JOHNSON,HEATHER FINLAY,BRANDON PARKHURST,JI JIANG,ZULAN PI,TAMMY C. WANG
申请号：
ARP130102559
公开号：
AR093281A1
申请日:
2013.07.18
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Pharmaceutical ingredients. 1. Claim 1: a compound characterized by formula (1),or a pharmaceutically acceptable stereoisomer, tautomer or salt thereof, wherein: R¹ is independently selected from halogen, CN, CO₂ (C₁₋₄ alkyl),-CO-R690,-CONH- (CH) -R1. Adoption of the agenda and organization of work.(substituted phenyl with 0-3r74919) and (heteromorphic with 5-6 members, including carbon atom and 1-4 heteromorphic atom selected from n.75808)；a. O and S (o)a. Use 0-3 r74919 instead of direct white；R² is independently selected in each case from halogen, OH, C₁₋₄ alkyl,C₁₋₄ alkoxy,haloalkyl C₁₋₄,haloalkoxy C₁₋₄,CN, NH₂,No.8322；NH (C₁₋₄ alkyl),N (C₁₋₄ alkyl) ₂,CO₂H, CO₂ (C₁₋₄ alkyl) and CONH₂；R3: selected independently: - so8322； - r8309y-nhrc8310a；R830808 independent selection: formula residuals (3) and (4)；R⁵ is independently selected from: C₁₋₆ alkyl substituted with 0-1 R⁹,C₂₋₆ alkenyl,haloalkyl C₁₋₆,C₁₋₆ alkoxy,- (CH₂) ₘ- (O) ₙ- (C₃₋₆ carbocycle substituted with 0-3 Rᵇ) and - (CH₂) ₘ- (O) ₙ- (5- to 6-membered heterocycle comprising carbon atoms and 1 - 4 heteroatoms selected from N, NRᶜ,a. O and S (o)a. The nonorthodox period is replaced by 0-2r749595；R⁶ is independently selected from: C₁₋₆ alkyl,C₂₋₆ alkenyl,C₁₋₆ alkoxy,haloalkyl C₁₋₄,- (CH₂) ₘ- (C₃₋₆ carbocycle substituted with 0 - 3 Rᵇ),-(ch8322) - 8344； - (piridilo replaced with 0-2 r74955)；-NH (apartment c832131)；-NHCH₂CO₂ (C₁₋₄ alkyl),-NH (4-halo-Ph)-Nhbn and other formulations (5)；R831183: conh832222；CONH (C₁₋₄ alkyl),CON (C₁₋₄ alkyl) ₂,SO NHSO (alquilo C)SO NH (CH) CO (alquilo C)NHSO₂NH₂,NHSO₂ (C₁₋₄ alkyl),N (alquilo C) SO NHN (CO -alquilo C) SO (alquilo C)e. So8322； r83044 and other formulas (6)；R83212: formula group (7),1. Phenyl and a 5 to 6-member heteromorphism, including carbon atom and 1-4 heteromorphism atom selected from n.758080；a. O and S (o)There, phenyl and heteromorphic substances are replaced by 0-2r1；R8313 independently selected halogen, Alcoy c8321c83318324；haloalkyl C₁₋₄,haloalkoxy C₁₋₄,NH.
