Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
发明人:
Andreas VON KNETHEN,Michael PARNHAM,Lisa Katharina SHA
申请号：
US16822240
公开号：
US20200215159A1
申请日:
2020.03.18
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention pertains to a fusion polypeptide for use in treating and/or preventing organ failure in a subject suffering from sepsis, said fusion polypeptide comprises at least (i) a first portion being a Fc portion of an immunoglobulin and (ii) a second portion comprising the extracellular portion of the human B7-H1 polypeptide or a variant thereof. Moreover, also encompassed by the invention is a polynucleotide encoding said fusion polypeptide for use in treating and/or preventing organ failure in a subject suffering from sepsis.
