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Extracellular histones as biomarkers for prognosis and molecular targets for therapy
专利权人:
OKLAHOMA MEDICAL RESEARCH FOUNDATION
发明人:
Charles T. Esmon,Jun Xu,Xiaomei Zhang
申请号:
US14734238
公开号:
US10350261B2
申请日:
2015.06.09
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to inflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death during sepsis. As such, they can be targeted pharmacologically by inhibitors, as well as used as biomarkers for prognosis of sepsis and other diseases.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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