Extracellular histones as biomarkers for prognosis and molecular targets for therapy

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专利权人:

Oklahoma Medical Research Foundation

发明人:

Zhang, Xiaomei,Esmon, Charles T.,Xu, Jun

申请号：

AU2008323947

公开号：

AU2008323947B2

申请日:

2008.11.06

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

Hyper-inflammatory responses can lead to a variety of diseases including sepsis.It is now shown that extracellular histones released in response to inflammatorychallenge are mediators contributing to endothelial dysfunction, organ failureand death during sepsis. As such, they can be targeted pharmacologically by inhibitors,as well as used as biomarkers for prognosis of sepsis and other diseases.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/