BUETTELMANN, Bernd,CECCARELLI, Simona M.,KUEHNE, Holger,KUHN, Bernd,NEIDHART, Werner,OBST SANDER, Ulrike,RICHTER, Hans
申请号：
ES13728748
公开号：
ES2577306T3
申请日:
2013.06.14
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compounds of formula (I) ** Formula ** in which: R1 and R2 together form a -CR14>； = CR15-CR16>； = CR17-, -CR14R15-O- (CR16R17) m-CR18R19-, -CR14R15- ( CR16R17) mO CR18R19-, -O-CR14R15- (CR16R17) m-CR18R19-, -CR14R15-NR22-CR16R17-CR18R19-, -CR14R15-S (O) 2-CR16R17-CR18R19-, - CR14R15-CR20R21- or - CR14R15-CR16R17- (CR18R19) p-CR20R21-； R3 is a substituted aryl, substituted heterocycloalkyl or substituted heteroaryl, wherein the substituted aryl, substituted heterocycloalkyl and substituted heteroaryl are substituted with R23 and may be further substituted with R24 and / or R25； R4 is H or alkyl； R5 and R6 are independently selected from H, alkyl and cycloalkyl； R7 is H, alkyl or cycloalkyl； A is NR8 or CR9R10； E is NR11 or CR12R13； R8 and R11 are independently selected from H, alkyl and cycloalkyl； R9, R10, R12 and R13 are independently selected from H, halogen, alkyl, haloalkyl and cycloalkyl； or R5 and R12, together with the carbon atoms to which they are attached, form a substituted cycloalkyl, substituted aryl, substituted heterocycloalkyl or substituted heteroaryl, in which the substituted cycloalkyl, substituted aryl, substituted heterocycloalkyl and substituted heteroaryl are substituted with R26 and may be further substituted with R27 and / or R28, in which in the case that R5 and R12 together with the carbon atoms to which they are attached form a substituted aryl or substituted heteroaryl, then R6 and R13 are absent； or R8 and R12, together with the nitrogen and carbon atoms to which they are attached, form a substituted heterocycloalkyl or substituted heteroaryl, in which the substituted heterocycloalkyl and substituted heteroaryl are substituted with R26 and may be further substituted with R27 and / or R28, in which, in case R8 and R12, together with the carbon atoms to which they are attached, form a substituted heteroaryl, then R13 is absent； or R9 and R11, together with the nitrogen and carbon atoms to which they are attached, form a substituted h
