CREMONESI, Susanna,MICHELI, Fabrizio,SEMERARO, Teresa,TARSI, Luca,LUKER, Tim,LESLIE, Colin
申请号：
ES15774987
公开号：
ES2687604T3
申请日:
2015.09.14
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound according to formula I, ** Formula ** where: A is selected from phenyl and heteroaryl； B is selected from phenyl and heteroaryl； L is a linker selected from alkylene and O； R1 is selected from H, alkyl, alkoxy, S-alkyl, S (O) qalkyl, COR5, CONR5R6, COOR5, CH2OH, OH, F and Cl； R2 is selected from NR7R8, CR11R12NR7R8, CONR7R8, (CR11R12) 2NR7R8 and (CR11R12) 3NR7R8, where R1 is alkyl, alkoxy, CH2OH, COR5, CONR5R6 or COOR5 when R2 is NR7R8； R3 is selected from H, alkyl, alkoxy, NR7R8, CH2OH, OH, F and Cl； or R2 and R3 are taken together with the carbon atoms to which they are attached to form a heterocyclyl or a heteroaryl, where the heterocyclyl or heteroaryl contain at least one member in the ring selected from N and NR13； with the proviso that when R2 and R3 are taken together with the carbon atoms to which they are attached to form a heterocyclyl or a heteroaryl, L is O； with the proviso that when R1 is H, or R2 and R3 are taken together with the carbon atoms to which they are attached to form a heterocyclyl； or R3 is selected from alkyl, alkoxy, NR7R8, CH2OH, OH, F and Cl； R4, R5 and R6 are each independently selected from H and alkyl； R7 and R8 are independently selected from H, alkyl, cycloalkyl, heterocyclyl and C (O) R10, where when R7 is C (O) R10, R8 is H or alkyl； or R7 and R8 can be taken together with the nitrogen atom to which they are attached to form a heterocyclyl； R9a, R9b, R9c, R9d, R9e and R9f are independently selected from H and alkyl； R10 is selected from alkyl, aryl, heterocyclyl and heteroaryl； ---- is absent or represents a link, where when ---- is a link R1 and R4 are absent； m is 0, 1 or 2； n is 0, 1 or 2； provided that the sum of m and n is 0, 1 or 2； q is 1 or 2； alkyl is a linear saturated hydrocarbon having up to 6 carbon atoms (C1-C6) or a branched saturated hydrocarbon of between 3 and 6 carbon atoms (C3-C6)； the alkyl may be optionally substituted with 1, 2, 3, 4 or 5 substituents selected from S-alkyl, S (O) alkyl, S (O) 2
