The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.本發明係關於梅嫩蛋白(menin)與MLL及MLL融合蛋白之相互作用之抑制劑、含有其之醫藥組合物及其用於治療癌症及由梅嫩蛋白-MLL相互作用介導之其他疾病之用途。