PROBLEM TO BE SOLVED: To provide a composition and a method for extending lifespan and delaying onset of age-related disease.SOLUTION: The invention provides a composition selected from a group consisting of oxaloacetate, oxaloacetic acid, oxaloacetate salt, α-ketoglutarate, and aspartate, and a method using an effective doses for extending lifespan. The composition is preferred to be an oral administration, a local administration, and a parenteral administration. As useful effects, weight loss, improvement of cardiac function, prevention of dermal aging, reduction of cancer development, osteoporosis, bone mass reduction, arthritis, cataract, macular degeneration and the like are included.SELECTED DRAWING: Figure 2【課題】個体の寿命を拡大させ、加齢関連疾患の発症を遅らせるための組成物、および方法の提供。【解決手段】オキサロアセテート、オキサロ酢酸、オキサロアセテート塩、α-ケトグルタレートおよびアスパルテートからなる群より選択される組成物、および有効な寿命拡大量を使用する方法。該組成物は、経口投与、局所投与、非経口投与であることが好ましい。有益な効果として、体重減少、心機能の改善、皮膚の老化防止、癌の発生低減、骨粗鬆症、骨量減少、関節炎、白内障、黄斑変性等が挙げられる。【選択図】図2
